The ISEH harnesses the power of engineering to restore and preserve health, and to eradicate targeted diseases.We are a cross-disciplinary alliance of scientists, clinicians, engineers, patients, and public leaders committed to developing step-wise solutions to some of the most complex and persistent challenges in human health. A defining feature of this initiative is its deliberate assembly of nontraditional, interdisciplinary teams—international and transgenerational researchers and scholars united by a shared intent: to strategically engineer technologies that eradicate targeted diseases. From pancreatic and ovarian cancer to heart attacks, strokes, and infectious diseases, we pursue sustained and coordinated progress towards addressing designated grand challenges rather than incremental breakthroughs.We seek to build collaborative human and technological systems where knowledge is shared, generations are linked, and credit is collective. We will drive impact over individual novelty, solutions over careers, and a positive sum culture. While pursuing the elimination of critical disease burdens, our ambition is for biomedical science to shift to a model that sustains health.From the moon landing to the human genome to the first image of a black hole, science has always been advanced by dreams bold enough to defy conventional limits. We continue that tradition—working across disciplines, generations, and geographies—because the next great health discoveries will not arise from predictable silos, but from the creative collisions among purpose-driven transdisciplinary collaborators.